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Development Trends and Suggestions of Nucleic Acid Vaccines

Li Aihua, Yang Xuemei, Sun Yinan, Yuan Yakun, Yang Juntao

Strategic Study of CAE 2021, Volume 23, Issue 4,   Pages 153-161 doi: 10.15302/J-SSCAE-2021.04.018

Abstract: Considering the urgent needs of coronavirus disease 2019 (COVID-19) epidemic prevention and control, nucleic acidvaccine has attracted great attention in the vaccine research and development (R&D) field owingParticularly, the R&D process of messenger RNA (mRNA) vaccine has significantly accelerated, andthe mRNA vaccine was approved for the first time to be marketed and used in humans.This article first summarizes the R&D status of nucleic acid vaccines from the aspects of related

Keywords： nucleic acid vaccine     deoxyribonucleic acid (DNA) vaccine     ribonucleic acid (RNA) vaccine     messengerRNA (mRNA) vaccine     coronavirus disease 2019 (COVID-19)     cancer    

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Optimising the oil phases of aluminium hydrogel-stabilised emulsions for stable, safe and efficient vaccine

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 6,   Pages 973-984 doi: 10.1007/s11705-021-2123-1

Abstract: Here, because of the varying oleic to linoleic acid ratio, soybean oil, peanut oil, and olive oil wereof oil phases and emulsion stability were unravelled, which showed that a higher oleic to linoleic acid

Keywords： pickering emulsion     vaccine adjuvant     alum-stabilised emulsion     oleic to linoleic acid ratio     stability    

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Nucleic acid crystallization and X-ray crystallography facilitated by single selenium atom

Wen Zhang,Jack W. Szostak,Zhen Huang

Frontiers of Chemical Science and Engineering 2016, Volume 10, Issue 2,   Pages 196-202 doi: 10.1007/s11705-016-1565-3

Abstract: strategy for 3-D structure determination of macromolecules, such as nucleic acids and protein-nucleic acidsuccessfully developed synthesis and strategy of selenium-derivatized nucleic acids (SeNA) for nucleic acid

Keywords： selenium     DNA     RNA     nucleic acid     crystallization    

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Invading target cells: multifunctional polymer conjugates as therapeutic nucleic acid carriers

Ulrich L?CHELT, Ernst WAGNER

Frontiers of Chemical Science and Engineering 2011, Volume 5, Issue 3,   Pages 275-286 doi: 10.1007/s11705-011-1203-z

Abstract: In the case of nucleic acid therapy, non-viral carriers face several biological barriers during the deliveryand conjugation of multifunctional polymeric structures for the utilization as “tailor-made” nucleic acid

Keywords： conjugate     DNA     gene transfer     polymer     RNA     targeting    

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Ribozyme and the mechanisms that underlie RNA catalysis

Timothy J. Wilson,Yijin Liu,David M. J. Lilley

Frontiers of Chemical Science and Engineering 2016, Volume 10, Issue 2,   Pages 178-185 doi: 10.1007/s11705-016-1558-2

Abstract: Mechanistically most fall into one of two classes, using either metal ions or general acid-base catalysisA sub-set of these use a combination of guanine base plus adenine acid to catalyze the cleavage reaction

Keywords： RNA catalysis     RNA structure     catalytic mechanism    

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Innovation-driven trend shaping COVID-19 vaccine development in China

Frontiers of Medicine doi: 10.1007/s11684-023-1034-6

Abstract: we outline representative vaccines in multiple routes, while the merits and plights of the existing vaccine

Keywords： SARS-CoV-2     COVID-19 vaccine     vaccine development    

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Anti RNA Viruses Related Biomaterials

Yao Kangde,Yin Yuji,Zhang Baolian,Zhao Liguo

Strategic Study of CAE 2003, Volume 5, Issue 7,   Pages 17-23

Abstract:

The structure, reproduction, replication and transcription of RNA viruses were introduced.Antivirus strategies including design of anti - SARS drugs, RNA interference, DNA vaccine delivery systemThese examples imply the interactions of RNA viruses with proteins, DNA, and polysaccharides.

Keywords： Anti-RNA viruses     protein     DNA     polysaccharide     biomaterials    

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RNA-Based Biocontrols—A New Paradigm in Crop Protection Review

Matthew Bramlett, Geert Plaetinck, Peter Maienfisch

Engineering 2020, Volume 6, Issue 5,   Pages 522-527 doi: 10.1016/j.eng.2019.09.008

Abstract: Over the last years, the RNA interference (RNAi) process has been identified as a very promising newRNA-based active ingredients (AIs) possess a unique mode of action and can be implemented via both geneticRNA-based AIs promise to deliver the selectivity and sustainability desired in future crop protectionresearch progress toward RNA-based biocontrols against the Colorado potato beetle (CPB), corn rootwormMany challenges still exist on the road to the implementation of a broad range of RNA-based products

Keywords： RNA-based biocontrols     RNA interference (RNAi)     Colorado potato beetle (CPB)     Corn rootworm (CRW)     Soy    

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Antitumor immunity of human SART3 gene vaccine against mouse tumor

HE Yu, YANG Shuhua, LIU Yong, LI Tao

Frontiers of Medicine 2008, Volume 2, Issue 1,   Pages 51-57 doi: 10.1007/s11684-008-0010-5

Abstract: After subcutaneous injection with SART3 gene vaccine, cytotoxic T lymphocyte (CTL) activity was measuredAnother group was treated with the vaccine after tumor implantation.It was found that human SART3 DNA vaccine can elicit a specific CTL reaction from the mouse splenocytesThe vaccine also shows activity in tumor treatment.We conclude that the human SART3 DNA vaccine can induce antitumor ability against tumor cells expressing

Keywords： antitumor therapy     occurrence     implantation     DNA vaccine     SART3 DNA    

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Knockdown of a Specific Circular Non-coding RNA Significantly Suppresses Osteosarcoma Progression Article

Shidong Wang, Hongliang Zhang, Bo Li, Chenglong Chen, Tingting Ren, Yi Huang, Kai Liu, Jingjing Li, Wei Guo

Engineering 2023, Volume 21, Issue 2,   Pages 187-193 doi: 10.1016/j.eng.2021.12.007

Abstract:

Osteosarcoma (OS) is a malignant mesenchymal tissue tumor known to occur in children and adolescents, and pulmonary metastasis often leads to death in these patients. The mechanism underlying OS progression remains unclear. Therefore, identifying new therapeutic targets and treatment modalities for OS is urgently needed. Abnormally expressed non-coding circular RNAs (circRNAs) are crucial for the occurrence and development of OS. The purpose of this study was to explore the expression and role of a novel circRNA circ_000203 in OS and elucidate the underlying mechanism. circ_000203 was demonstrated highly expressed in OS cell lines and tissues, and circ_000203 knockdown significantly inhibited OS progression in vitro and in vivo. Furthermore, we found that circ_000203 is a sponge of miR-26b-5p, an upstream regulator of bone morphogenetic protein receptor 2 (BMPR2). Thus, the overexpression of BMPR2 could reduce the inhibitory effect on OS progression. This indicates that knockdown of circ_000203 suppresses OS progression through microRNA (miRNA)-mediated BMPR2 downregulation. Our findings provide important insights for understanding the occurrence and development of OS. 

Keywords： Non-coding RNA     Osteosarcoma     CircRNA     Molecular mechanism     Knockdown    

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Broadly neutralizing antibodies and vaccine design against HIV-1 infection

Qian Wang, Linqi Zhang

Frontiers of Medicine 2020, Volume 14, Issue 1,   Pages 30-42 doi: 10.1007/s11684-019-0721-9

Abstract: However, vaccine development has remained challenging.in broadly neutralizing monoclonal antibodies (bNAbs) has led to the development of multiple novel vaccineOur review aims to highlight these discoveries and rejuvenate our endeavor in HIV-1 vaccine design and

Keywords： HIV-1     broadly neutralizing antibodies     Env conformational states     vaccine design     SOSIP    

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Protection of inactivated vaccine against SARS-CoV-2 infections in patients with comorbidities: a prospective

Frontiers of Medicine   Pages 867-877 doi: 10.1007/s11684-023-0995-9

Abstract: The protection against SARS-CoV-2 infection of the Sinopharm vaccine was similar in participants with

Keywords： COVID-19     Sinopharm/BBIBP vaccine     immunocompromised patients     real-world    

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Blockage of receptor-interacting protein 2 expression by small interfering RNA in murine macrophages

LIU Hongchun, CAO Zhongwei, JIN Jianjun, WANG Jiyao

Frontiers of Medicine 2008, Volume 2, Issue 2,   Pages 166-170 doi: 10.1007/s11684-008-0030-1

Abstract: Murine Rip2 small interfering RNA (siRNA) plasmids were constructed and transfected into macrophage and
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Overexpressed long noncoding RNA CRNDE with distinct alternatively spliced isoforms in multiple cancers

Xuefei Ma, Wei Zhang, Rong Zhang, Jingming Li, Shufen Li, Yunlin Ma, Wen Jin, Kankan Wang

Frontiers of Medicine 2019, Volume 13, Issue 3,   Pages 330-343 doi: 10.1007/s11684-017-0557-0

Abstract: CRNDE is a long noncoding RNA with alternative splicing and is implicated in the pathogenesis of several

Keywords： long noncoding RNA     CRNDE     alternative splicing    

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Immunogenicity and protective immunity against otitis media caused by pneumococcus in mice of Hib conjugate vaccine

Zeyu Chen,Rong Guo,Jianghong Xu,Chuangjun Qiu

Frontiers of Medicine 2016, Volume 10, Issue 4,   Pages 490-498 doi: 10.1007/s11684-016-0470-y

Abstract: and protective immunity of a Hemophilus influenzae b (Hib) polysaccharide conjugate vaccineA total of 15 young mice aged 3 weeks to 5 weeks were immunized with the conjugate vaccine, and another15 young mice of the same age were immunized with the licensed Hib-tetanus toxoid (TT) vaccine.This new Hib-PsaA conjugate vaccine can induce both anti-PsaA and anti-Hib immune responses in young

Keywords： conjugate vaccine     pneumococcal surface adhesin A     Hemophilus influenzae b     immunogenicity     otitis media    

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Title Author Date Type Operation

Development Trends and Suggestions of Nucleic Acid Vaccines

Li Aihua, Yang Xuemei, Sun Yinan, Yuan Yakun, Yang Juntao

Journal Article

Optimising the oil phases of aluminium hydrogel-stabilised emulsions for stable, safe and efficient vaccine

Journal Article

Nucleic acid crystallization and X-ray crystallography facilitated by single selenium atom

Wen Zhang,Jack W. Szostak,Zhen Huang

Journal Article

Invading target cells: multifunctional polymer conjugates as therapeutic nucleic acid carriers

Ulrich L?CHELT, Ernst WAGNER

Journal Article

Ribozyme and the mechanisms that underlie RNA catalysis

Timothy J. Wilson,Yijin Liu,David M. J. Lilley

Journal Article

Innovation-driven trend shaping COVID-19 vaccine development in China

Journal Article

Anti RNA Viruses Related Biomaterials

Yao Kangde,Yin Yuji,Zhang Baolian,Zhao Liguo

Journal Article

RNA-Based Biocontrols—A New Paradigm in Crop Protection

Matthew Bramlett, Geert Plaetinck, Peter Maienfisch

Journal Article

Antitumor immunity of human SART3 gene vaccine against mouse tumor

HE Yu, YANG Shuhua, LIU Yong, LI Tao

Journal Article

Knockdown of a Specific Circular Non-coding RNA Significantly Suppresses Osteosarcoma Progression

Shidong Wang, Hongliang Zhang, Bo Li, Chenglong Chen, Tingting Ren, Yi Huang, Kai Liu, Jingjing Li, Wei Guo

Journal Article

Broadly neutralizing antibodies and vaccine design against HIV-1 infection

Qian Wang, Linqi Zhang

Journal Article

Protection of inactivated vaccine against SARS-CoV-2 infections in patients with comorbidities: a prospective

Journal Article

Blockage of receptor-interacting protein 2 expression by small interfering RNA in murine macrophages

LIU Hongchun, CAO Zhongwei, JIN Jianjun, WANG Jiyao

Journal Article

Overexpressed long noncoding RNA CRNDE with distinct alternatively spliced isoforms in multiple cancers

Xuefei Ma, Wei Zhang, Rong Zhang, Jingming Li, Shufen Li, Yunlin Ma, Wen Jin, Kankan Wang

Journal Article

Immunogenicity and protective immunity against otitis media caused by pneumococcus in mice of Hib conjugate vaccine

Zeyu Chen,Rong Guo,Jianghong Xu,Chuangjun Qiu

Journal Article